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Showing 3 results for Asghari
Study of changes in lipoprotein (a) level in streptozotocin-induced diabetic rats treated with aqueous extract of berberis vulgaris
Mina Hemmati, Elham Zohoori, Somayeh Asghari,
Volume 2, Issue 1 (5-2014)
Abstract
Background & Objective: Dyslipidemia increases the risk of developing cardiovascular diseases in diabetic patients. Lipoprotein a, as a cholesterol carrier and competitive inhibitor of plasminogen in the blood coagulation system is considered an atherogenic factor which increases the risk of developing atherosclerosis in diabetic individuals. Based on previous studies, Barberry is thought to lower cholesterol and triglyceride levels. Since increased cholesterol level, especially Lipoprotein a, increases the risk of cardiovascular diseases in people with diabetes, the aim of this study was to evaluate serum levels of Lipoprotein (a) in diabetic rats treated with aqueous extract of Barberry. Method: In this experimental study, diabetes was induced in 15 mice by intraperitoneal injection of streptozotocin (STZ) and then they were treated orally for 14 days with liquid extract of the said plant in doses of 25 and 100 mg/kg. At the end of the treatment period, mice were kept fasted for 12 hours and then by heart phlebotomy, serum levels of Lipoprotein a, serum levels of glucose, triglycerides, total cholesterol, HDL and LDL were measured in normal and diabetic groups. The results were then analyzed using SPSS version 16, ANOVA and Tukey›s test. Results: Data analysis showed that the consumption of both oral doses of Berberis vulgaris (Barberry) in diabetic rats causes a significant reduction in serum levels of triglyceride, serum glucose and VLDL(P=0.01). The extract at both used doses also significantly reduced serum levels of lipoprotein (a) in treated diabetic rats (P=0.012). Conclusion: Oral administration of the aqueous extract of Berberis vulgaris (Barberry) is effective for reducing triglyceride and glucose levels in diabetic mice. Since Barberry lowers Lipoprotein (a) levels, it can be considered as an anti-atherogenic factor.
How is Coronavirus distributed in the world? A Spatial-Temporal Assessment Using Geographic Information System Approach
Sayede Shadi Nazari , Solmaz Norouzi, Mohammad Asghari Jafar-Abadi,
Volume 8, Issue 1 (3-2020)
Abstract
Background and objective: Prevalence and the spread of novel Coronavirus (2019-ncov) cause significant life and financial destruction worldwide and is the cause of severe respiratory infection in humans. The present study briefly reviews the latest information on how the virus is distributed around the world. The main question of the study are: 1- In which geographic regions of the world is the Coronavirus more concentrated? 2- Is the distribution of the Coronavirus geographically stable?
Material and Methods: To answer these questions, we first began collecting and studying the available scientific resources. The required data was obtained from a daily report of confirmed, recovered, and deaths by the Coronavirus separated by state which was collected from January 22, 2020 to Jun 19, 2020. Based on analyzing available patterns in spatial statistics tool in ArcGIS and geostatistical models, we examined how the Coronavirus was distributed around the world.
Results: The spread of the disease is increasing all over the world. Using the results of Map 1, it is seen that the spread of Corona virus has a trend and starts in China and then spreads to the Middle East, Europe and the United States in a linear manner. The results also show that the prevalence of mortality is higher than that of recovery. Central mean and median for all types (Confirmed, Recovered and death) are close to each other. Death mean and median was close to Western countries and Recovered mean and median was close to Eastern countries, while confirmed mean and median was located in the center.
Conclusion: Based on spatial statistics tool in ArcGIS and geostatistical models, we examined how the Coronavirus was distributed around the world. Our results showed that the spread of Corona virus had a trend and started in China and then spread to the Middle East, Europe and the United States in a likely linear manner.

The effect of eight weeks of high-intensity interval training with spirulina supplementation on apoptotic markers in the hippocampal tissue of high-fat diet-induced obese rats
Soraya Pourasghari Siah Astalkhi , Seyed Morteza Tayebi, Lida Moradi, Rasoul Eslami,
Volume 12, Issue 3 (12-2024)
Abstract
Background: Obesity leads to neuronal apoptosis and cognitive impairment by increasing inflammation and oxidative stress. Although the beneficial role of exercise and antioxidant supplements have been reported separately, their interactive effect on neuronal apoptosis in obesity is still not well known. Therefore, this study aimed to investigate the effect of eight weeks of HIIT with Sp supplementation on apoptotic markers in the hippocampal tissue of high-fat diet-(HFD) induced obese rats.
Methods: In this experimental study, 24 obese male Sprague-Dawley rats (60% fat, 20% protein, and 20% carbohydrates) were randomly divided into four groups of six rats, including 1) HFD, 2) HFD+Sp, 3) HFD+HIIT, and 4) HFD+HIIT+Sp. Also, six healthy rats were selected as the HC group to investigate the effects of HFD on research variables. Subsequently, HIIT was performed for eight weeks, three sessions per week with an intensity of 80-110% of maximum running speed and 2-8 high-intensity intervals. Also, Sp supplement was taken orally during this period with a dose of 100 mg/kg/day. Bax and BCL-2 levels were measured with qRT-PCR method. One-way analysis of variance and Tukey's post-hoc tests were used for statistical analysis of data (p ≤0.05).
Results: In the HFD+HIIT and HFD+HIIT+Sp groups, Bax levels and Bax/BCL-2 ratio were lower and BCL-2 levels were higher than the HFD group (p=0.001). In the HFD+Sp group, BCL-2 levels were higher and Bax/BCL-2 ratios were lower than HFD group (p=0.008). Also, in the HFD+HIIT and HFD+HIIT+Sp groups, Bax levels and Bax/BCL ratio were lower and BCL-2 levels were higher than HFD+Sp group (p≤0.05). In addition, in the HFD+HIIT+Sp group, Bax levels were lower and BCL-2 levels were higher than in the HFD+HIIT group (p≤0.05).
Conclusion: It seems that although HIIT and Sp supplement separately have an anti-apoptotic effect, their interactive effect on inhibiting neuronal apoptosis in brain tissue in obesity conditions is more obvious than the effect of each one alone.
 

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