Roghieh Golsha, Nona Gorgitabar, Behnaz Khodabakhshi, Abdullah Abbasi, Hamed Kalani,
Volume 8, Issue 1 (3-2020)
Abstract
Background and objective: Currently, due to an increase in the number of individuals with immune deficiency, long-term chemotherapy, and underlying diseases, an appropriate situation has been provided for the development of opportunistic infections, including fungal infections. This study was conducted with the aim of evaluating clinical symptoms, laboratory findings, and the treatment outcome of mucormycosis in diabetic individuals.
Material and Methods: In this cross-sectional retrospective study, all recorded cases of mucormycosis in the health centers of Gorgan city, northeast of Iran, in diabetic individuals were extracted during 15 years from 2002 to 2016. All information was extracted from patient-related records and then was analyzed. In the period from 2002 to 2016, 12 diabetic individuals with mucormycosis were referred to health centers.
Results: There were statistically significant differences in the categories of sex, residence, education, taking drug, addiction, diabetes status, methods of diagnosis, involved area with mucormycosis, treatment type of mucormycosis, and treatment outcome of mucormycosis. Furthermore, no statistically significant difference was observed in the categories of age, underlying diseases (other than diabetes), hospitalization, and diagnostic time.
Conclusion: Due to the rareness or lack of an appropriate diagnostic method, and in addition, due to lack of an appropriate treatment, attention should be paid to invasive mucormycosis in individuals with immunodeficiency.
Azar Mohammadi, Abdolhossein Taheri Kalani, Mahnaz Omidi,
Volume 12, Issue 1 (10-2024)
Abstract
Background: When metabolic demands increase due to an obesity-induced high-fat diet (HFD), mitochondrial function is impaired, production can increase, and oxidative stress occurs. This type of stress has been shown to play a key role in various pathological conditions such as heart disease, hypertension, diabetes, chronic kidney disease, and cancers. This study aims to evaluate the impact of HFD and resistance training (RT) on oxidative stress biomarkers and cardiac health in rats.
Methods: In this experimental study, 21 male Wistar rats (weighing 200-300 g) were randomly and equally assigned into the following groups: control (CTRL), HFD, and HFD+ RT. Animals in the HFD groups received a high-fat diet for 23 weeks. During the treatments, rats in the HFD+ RT group, besides receiving a high-fat diet, performed the progressive RT protocol three times per week with 30- 100% of their body mass in the last eight weeks. At the end of the treatments, superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), and malondialdehyde (MDA) levels in cardiac tissue were measured by colorimetric method. The data were analyzed by one-way analysis of variance (ANOVA) and Tukey’s post hoc test at a significant level of P<0.05.
Results: HFD did not alter levels of SOD, GPX, TAC, or MDA in cardiac tissue. Cardiac SOD (P=0.021), GPX (P=0.024), and TAC (P=0.041) levels in the HFD+ RT increased significantly compared to the HFD group, but there was no significant difference in cardiac MDA levels between the three groups (P=0.438).
Conclusion: RT seems to improve cardiac tissue oxidative stress adaptations in an animal model fed with an HFD.
