Dr Omid Mozafari, Dr Ayyoob Khosravi,
Volume 6, Issue 3 (9-2018)
Abstract
Dear Editor,
I would like to point out some issues regarding the article entitled "Sayyed Ismael Jorjani, The famous Iranian physician and philosopher" by Seyyed Alireza Golshani that has been published in the journal of Jorjani Biomedicine Journal Volume 2, Issue 2 (Autumn 2014 & winter 2015 2014) and is about the great 11th-12th century physician, Ismael Jorjani.
Zahra Roustaeizade, Mohamad Hassan Akhavan Karbassi, Khatereh Kheirollahi, Ehsan Babaei Zarch,
Volume 6, Issue 3 (9-2018)
Abstract
Background and objectives: Recurrent aphthous stomatitis (RAS) is a painful ulcerative lesion and its incidence is 20% in the society. Myrtus communis (myrtex) has been effective in the treatment of RAS. In this study, two different concentrations (2.5% versus 5%) of myrtex extract were evaluated to discover the most effective concentration for the treatment of RAS.
Methods: In this randomized, double-blind clinical trial, 60 patients with RAS were evaluated. Thirty patients used myrtex extract 5% and thirty patients used myrtex extract 2.5% (10 drops on lesion for 20 seconds 5 times per day). The severity of pain and burning sensation experienced by patients were measured by visual analogue scale (VAS) and the size of the lesion was estimated by transparent calibrated grid Data analysis was done by running t-test and repeated measures statistical test.
Results: The mean of the largest RAS diameter before treatment was decreased in both groups 1 day and 7 days after treatment (P-value=0.000); however, these differences were not significant in both groups (P-value =0.401). Furthermore, the severities of pain and burning sensation were decreased in both groups (p-value = 0.000). Nevertheless, this decrease was similar in both groups (P-value = 964).
Conclusion: Treatment with different concentrations of myrtex extract is effective in decreasing RAS diameter, pain, and burning sensation. In addition, the therapeutic efficacy of two different concentrations of myrtex extract (2.5% and 5%) was similar in this regard.
Ali Ahmadi , Neda Soleimani, Parham Abedini ,
Volume 6, Issue 4 (12-2018)
Abstract
Background and objectives: Bacterial antibiotic resistance is a major issue in the process of infectious disease treatments. The aim of this study was an evaluation of the antibacterial activity of Punica granatum flower extract against several gram-negative and positive clinical bacterial isolates.
Methods: An adequate dried flower of an endemic mature Punica granatum plant was used for extraction. The standard strain of several gram negative and positive bacteria was chosen for this study, as well as some distinguished clinical strains such as Pseudomonas aeruginosa and Enterococcus spp. In order to indicate the antibacterial effect of Punica granatum mature flower, well-diffusion method was done for each bacterium of the extraction of the flower, so that zone inhibitions can be reported. MIC and MBC test was done.
Results: Disc diffusion test was done and the greatest zone inhibition Shigella was 39 mm and then Salmonella typhimurium 13.1 mm. The lowest antibacterial effect of P. granatum extraction was gained on Proteus with 6 mm of zone inhibition. The Highest MIC and MBC effect was obtained from antibacterial evaluation on S. typhimurium and S. epidermidis.
Conclusion: the antibacterial activities of medicinal plants, pharmaceutical companies are just using medicinal plants in association with synthetic drugs in order to obtain better results. Setting up a more analytic test on medicinal plants same as HPLC test could be the next stage of this study in order to reach to a higher reliance of medicinal plants antibacterial activities qualification So That we could combine them with synthetic drugs and improve their efficiency.
Abolfazl Jafari-Sales, Parisa Bolouri,
Volume 6, Issue 4 (12-2018)
Abstract
Background and objectives: Today, due to the increasing antibiotic resistance of bacteria, the use of medicinal plants as a suitable alternative to antibiotics has increased significantly; therefore, in this study, the antibacterial effects of methanolic extracts of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa and Escherichia coli were evaluated.
Methods: In this laboratory research, after collecting plants and confirming its scientific name, extract of Glycyrrhiza glabra L. Root was prepared by Soxhlet extractor method at concentrations of 20 mg / ml to 400 mg / ml. Then the antimicrobial effects of this extract were investigated using Agar well diffusion and Dilution test methods.
Results: The results showed that the methanolic extracts of G.glabra L. in both Agar well diffusion and Dilution test methods had antibacterial effects on the tested bacteria. The highest effect was observed on S.aureus and the lowest effect was observed in P.aeruginosa.
Conclusion: According to the above results, it can be expected that the G.glabra L. extract can be used to treat bacterial infections and is a suitable alternative to commonly used chemical treatments for the treatment of infections.
Bahareh Yazdanparast Chaharmahali, Mohammad Ali Azarbayjani, Maghsood Peeri, Parvin Farzanegi Arkhazloo,
Volume 6, Issue 4 (12-2018)
Abstract
Background and objectives: Elderly is characterized by decreased cardiac function, which is widely associated with mitochondrial failure in cell death. Elderly causes heart apoptosis. Although the old heart is vulnerable to apoptosis, physical training and some supplements through different mechanisms could be effective in reducing apoptosis. The present study aimed to investigate the effect of interval training on some apoptotic parameters of Bax and Bcl2 cardiomyocytes in old female rats.
Methods: In an experimental study, 49 Wistar female rats (2 years old) were randomly assigned into 7 groups: control, saline, curcumin, moderate intensity training, moderate intensity training + curcumin, high intensity training, high intensity training + curcumin. The experimental groups received gavage doses of curcumin 30 mg / kg body weight three days a week via. The saline group also received the same amount of saline. Training groups had moderate and severe exercises on the treadmill for eight weeks, and three sessions per week. Forty-eight hours after the last training session and gavage, the animals were killed and their heart tissues were isolated to determine the levels of Bax and Bcl2.
Results: The results indicated that interval training and curcumin consumption could significantly increase the levels of Bcl2 and BAX and the BAX / Bcl2 ratio, the amount of which depends on the intensity of training. Moreover, the combination of training and curcumin had an antagonistic effect.
Conclusion: According to the results, physical activity and curcumin separately have a protective effect on the heart tissue; however, these two interventions do not enhance each other’s effect. Hence each one is suggested to be used separately.
Majid Amini Khorasgani , Parisa Mohammady Nejad, Mohammad Mehdi Moghani Bashi,
Volume 6, Issue 4 (12-2018)
Abstract
Background and objectives: One of the latest studies in the genetics field is the evaluation of role of micro-RNAs as a biomarker for diagnosis of multiple sclerosis (MS), which is a demyelinating disease of the central nervous system (CNS) and emerges in the form of numerous small and large plaques in white matter in the brain and spinal cord. This disease could be associated with several complications, including reduced vision, spasticity and imbalance, and impaired sphincter control. MiR-202-3p is an intronic miRNA located in the ADA (Adenosine Deaminase) gene, which is the main enzyme involved in the pathway for the conversion of adenosine into inosine. Moreover, ADA regulates the inflammatory response and protection of tissue from damage as a strong complementary mechanism. This study aimed to evaluate the expression level of miR-202-3p in individuals diagnosed with relapsing-remitting multiple sclerosis (RRMS) and healthy individuals in Isfahan, Iran.
Methods: This analytical-observatory study was performed on 49 RRMS patients and 52 healthy individuals with no history of autoimmune and inflammatory diseases. Total RNA was extracted from blood lymphocytes by Ficoll and Trizol. Afterwards, cDNA was formed using a special miRNA cDNA kit, followed by the application of Real-time RT PCR to measure the expression of miR-202-3p in healthy individuals and patients.
Results: According to the results, the miR-202-3p expression was higher in patients, compared to healthy individuals (P=0.006). In addition, the sensitivity and diagnostic value of this miRNA in receiver operating characteristic (ROC) curve analysis were equal to AUC=0.80 (area under the curve).
Conclusion: In line with other studies, our findings demonstrated that miR-2023p can be used as a biomarker in the diagnosis of MS. In addition, it seems that miR-202-3p acts as an immunosuppressant by inhibiting ADA gene, which regulates various processes related to inflammatory response and maintenance of tissue from damage.
Roohollah Gholikhani, Farbod Ebadi Fard Azar, Mohammad Javad Kabir, Mohammad Mehdi Tadayon,
Volume 6, Issue 4 (12-2018)
Abstract
Background & Objctives: With regard to unclear government approach in the insurance sector, multiplicity of rules, high share of households, improper population coverage and lack of cost-effective interventions, this study aimed to analyze the current status of basic health insurance in Iran and its distance from the desirable status according to upstream documents. In addition, we attempted to propose a strategy in this regard.
Methods: This qualitative research was performed in 2017 in four stages of analysis of the current status of upstream documents and laws, round-table discussions of policy-makers, and presenting political options. In total, 20 subjects were selected by targeted sampling method with maximum diversity and based on the saturation rule. Data were collected by document analysis and interviews with authorities. Moreover, data were analyzed applying content analysis and the deductive approach.
Results: The results were classified into five areas of population coverage, financial resources management, financial protection of insured individuals, strategic purchasing, policy-making, and structure. There was a significant distance between the desirable status based on upstream documents and laws and the current status. Recommendations: eliminating conflicts of interest in decision-making areas, complying with the public interest in making health decisions, observing the principles of the evaluation of regulatory effects, and assessing the economic and social effects of health decisions.
Conclusion: Despite the successful global experiences, the recommendations of the World Health Organization, and the existence of several optimal structures, proper models must be considered by the health system of the country through observing the relevant mechanisms and necessities.
Masoud Aman Mohammadi, Mohammad Reza Rostami, Mojtaba Raeisi, Mahnaz Tabibi Azar,
Volume 6, Issue 4 (12-2018)
Abstract
Preparation of nano-microfibers from biopolymers (e.g., proteins and polysaccharides) by using electrospinning technology has been considered by researchers due to the formation of fibers or particles at the nano and micrometer scales, high porosity level, adjustable dewatering behavior, and special mechanical behavior. These products can be used in the microencapsulation of bioactive compounds, stabilization of enzymes and smart packaging. In the electrospinning method, a high voltage is used to create a nanofibers-particles. When the electric field overcomes the surface tension of the droplet, a jet exits the polymeric solution and is formed along the collector surface as it stretches toward the collector panel of the nanofiber. Parameters including molecular weight and polymer microstructure characteristics such as electrical conductivity, viscosity, surface tension, and the electrical potential applied by the device, solution flow rate, distance between the tip of the needle and the collector plate and sometimes the material of the collector plate are effective in the formation of electrospun fibers and particles. In this review, we discussed and evaluated the production stages, the strengths and weaknesses of the fibers produced from proteins and polysaccharides, and their functional properties and potentials, especially in food and drug sciences.
Habibollah Esmaily, Somaye Barzanouni, Hamid Farhangi,
Volume 6, Issue 4 (12-2018)
Abstract
Abstract
Background and objectives: Leukemia is one of the most prevalent cancers worldwide. The relapse of the disease mitigates patient survival time. The convenience of explaining the results obtained from analyzing tree models have encouraged doctors and paramedics to employ them in their research. The current study is an attempt to determine the five-year survival time and factors influencing it in children suffering from acute lymphoblastic leukemia based on tree survival model in the presence of competing risks.
Methods: The required data were collected from 255 children younger than 15, who suffered from acute lymphoblastic leukemia and referred to Dr. Sheikh Hospital in Mashhad, Iran during the years 2007-2015. Afterwards, the survival of the patient until the end of March 2015 was scrutinized. In this regard, various variables like sex, age, treatment period, white blood cells count, hemoglobin, platelet count, LDH level, CNS involvement, mediastan mass, rheumatologic symptoms, etc. were also considered.
The relapse of the disease was considered the desired event, whereas the relapse-free death is called competing event. The survival time of the patients from diagnosis date to the date of event (censoring) was calculated on a monthly basis. The fitting of the model is implemented according to maximum within-node homogeneity, which, in turn, is based on the partition function of sum of squares of Event-Specific Martingale Residual changes.
Results: The estimated mean survival time during the relapse and relapse-free death periods as well as in the presence of either events was obtained 55.51, 47.53 and 44.20 months, respectively, implying a decrease in the mean survival time in the presence of competing risks. White blood cell count and platelet count were considered the most influential factors contributing to the relapse or survival. Three sub-groups of patients at risk were identified, and those with white blood cells ≥ 50000 were recognized as the ones with the least mean survival time.
Conclusion: The factors affecting the survival rate of patients and their spots in the model can be employed in making clinical decisions and proposing therapeutic protocols. Identification of sub-groups with identical mean survival rate is the most salient capabilities of the research model.
Dr. Mahdi Azarnoosh, Mr. Hojjat Doostdar Noghabi,
Volume 6, Issue 4 (12-2018)
Abstract
Background and objectives: The importance of continuous monitoring and rapid and accurate informing of changes in blood components (e.g., percentage of hematocrit [HCT]), especially in acute conditions, has motivated researchers to use non-invasive measurement methods. Therefore, this study aimed to evaluate the association between blood HCT and photoplethysmographic signal and the possibility of increasing the accuracy of its measurement by optical method at three specific wavelengths.
Methods: In this study, photoplethysmographic signals were recorded at three different wavelengths for 25 male and female subjects (mean age of 37.56±10.40 years), who referred to the laboratory to assess their blood HCT percentage. We extracted the peak value of the signal after calibrating a special probe with a standard pulse oximetry system and applying the necessary preprocesses on the received signal. Eventually, in addition to the estimation of HCT level, we assessed the level of correlation between the optical method results and laboratory data applying Pearson’s, Kendall’s, and Spearman’s correlation coefficients.
Results: Comparison of HCT measurement by the optical method and reference levels measured by standard laboratory technique in 25 subjects showed a mean error of 0.6±0.25%. In addition, evaluation of the relationship between data of the percentage of laboratory HCT with mean of 43.43±3.43 and data obtained by photoplethysmographic signals with mean of 43.31±3.27 by three Pearson’s, Kendall’s, and Spearman’s methods demonstrated that the data of the two techniques had a significant correlation of 0.949, 0.860, and 0.955, respectively (P<0.01).
Conclusion: Given the high correlation of characteristics of the photoplethysmographic signal at three wavelengths with blood HCT and level of accuracy of our findings, the proposed method could be exploited for accurate, clean and cost-effective monitoring of HCT level.
Jamshid Banaii Broojeni, Saeed Keshavarz, Iman Zakavi,
Volume 7, Issue 1 (3-2019)
Abstract
Background and objectives: The purpose of the present study was to examine the effect of a progressive resistance-training program beside an energy deficit diet on body Composition, insulin resistance and plasma adiponectin levels in overweight adult men.
Methods: Twenty-five overweight men (age =32.1 ± 4.3 years, BMI =28.9 ± 1.3 kg.m-2) were randomly assigned into one of the two groups: resistance training+ diet (RD, n =15); and diet only (DO, n =12). Both groups undertook a 12-week weight loss program using a moderate isocaloric energy deficit.
Results: After 12 weeks intervention, there was equivalent significant weight loss for both groups (p <0.01). Total and abdominal fat mass, fasting insulin concentration and HOMA-IR score were decreased in both groups (p <0.01). All previously mentioned variables except fasting insulin levels were more significantly reduced in RD compared to DO group. There was a significant decrease in lean body tissue only in DO (p <0.01) group. We did not find any significant changes in plasma adiponectin concentration of the experimental groups. Reduction in insulin resistance had a significant positive correlation with abdominal and total fat loss (p < 0.05) and a negative correlation with lean mass loss (p < 0.05).
Conclusion: Adding a progressive resistance-training program to an energy deficit diet, without any change on magnitude of weight loss could prevent the loss of lean body mass and improve the reduction of total and abdominal fat mass and insulin resistance. Moreover, the change in body composition and insulin resistance was accompanied with no significant change in plasma adiponectin.
Mahdi Saravani, Omid Mozafari,
Volume 7, Issue 1 (3-2019)
Abstract
ABSTRACT
Background and objectives: Varicocele has a relatively high prevalence in men and is a major cause of infertility in men. The disease has been discussed extensively in Persian medicine textbooks. Considering the importance of infertility and its impact on mental health and quality of life, we aimed to review the Persian medicine (Iranian Traditional Medicine) literature on the underlying causes, the process and treatment of varicocele.
Methods: This descriptive review was carried out using 13 most authoritative sources of Persian medicine with the help of the Noor software. The search was conducted using the following keywords in their Persian medicine equivalents: "varicose", "testicles", "gonads" and "scrotum".
Results: Varicocele was defined as tortuous dilation of testicular veins and their surroundings. Because of the coldness and the weaker nature of the left testicle, varicocele is more prevalent on this side. This could be related to the reduced purification of materials due to the path of left testicular arteries. For the treatment of this disease, the Persian medicine recommends a set of measures including dietary modifications, some oral and topical medications, and even phlebotomy.
Conclusion: Studying the Persian medicine literature and utilizing the recommended therapies (after updating and confirming their efficacy in evidence-based research) can provide cost-effective, safer and simpler therapeutic approaches that can be complementary to the current therapies.
Khatereh Kheirollahi, Seyyed Hossein Hekmati Moghadam, Gooya Kabir, Zhaleh Zare Mehrjardi,
Volume 7, Issue 2 (7-2019)
Abstract
Background and objectives: patients undergoing Chemotherapy are severely susceptible to infections due to a compromised immune system and also their oral cavity is a great place for microorganisms and fungi to grow. The aim of this study was to determine the distribution of different strains of Candida from oral lesions of these patients.
Methods and Materials: This descriptive study was performed on 128 patients undergoing chemotherapy in teaching hospitals of Yazd, which was three weeks pass receiving their first medicine. Oral samples were prepared from swabs and then cultured in Sabouraud dextrose agar culture media for evaluation of yeast growth, colonization, and identification of species. Samples were examined under the microscope and recorded. Finally, the data were analyzed by SPSS17 software, Chi-square, and Man-Whitney tests.
Results:128 patients participated in this study, which included 45 males (35.15%) and 83 females (64.85%) with an average age of 40.16 ± 19.95 years. 84 patients (62.65%) had candida in their oral cavity, of which 79 were candida albicans and 5 were Non-albicans Candida. No significant correlation was found between the type of candidates, type of cancer and the frequency of Candida albicans with the age and sex of the patients (P-value <0.05).
Conclusion: Based on the results of this study, the prevalence of Candida albicans in patients undergoing chemotherapy is higher than Non-albicans Candida. Patients with leukemia are more susceptible to Candida infections.
Paria Motahari, Fatemeh Pournaghi Azar, Parisa Rasouly,
Volume 7, Issue 3 (9-2019)
Abstract
Background and objectives: Most studies have identified interferon-gamma (IFN-γ) as a key role in the pathogenesis of oral lichen planus (OLP). Recent studies have also shown a link between IFN-γ (+874 A/T) gene polymorphism and OLP. The purpose of the present meta-analysis is to investigate the relationship between IFN-γ (+874 A/T) gene polymorphism and susceptibility to OLP.
Methods: A systematic search of resources to investigate the association between IFN-γ and OLP from Google scholar, PubMed, Embase, Cochrane, Scopus, Proquest, Ovid and Web of science (from 2000 to April 2019) completed. Two individuals independently assessed the quality of the articles. Endnote X5 resource management software was used to organize, study titles and abstracts as well as identify duplicates. A random effect model was also used to perform the meta-analysis.
Results: Four IFN-γ (+874 A/T) polymorphism studies with 297 patients in the case group and 621 healthy controls in the 4 different countries were included. After meta-analysis, a significant association was found between IFN-γ polymorphism (+874 A/T) and OLP. (T vs A: odds ratio (OR) = 1.62; 95% CI = 1.28-2.04; TT vs AA: OR = 2.67; 95% CI = 1.6- 4.45; AT vs AA: OR = 1.56; 95% CI = 1.6- 4.45; TT vs AT + AA: OR = 1.73; 95% CI = 1.13-2.64; AT + TT vs AA: OR = 1.75; 95% CI = 1.28-2.43)
Conclusion: Based on this meta-analysis, there was a positive relationship between IFN-γ (+874 A/T) gene polymorphism and the risk of OLP. The findings showed that increasing TT genotypes significantly increased susceptibility to OLP in comparison with other genotypes.
Seyed Hossein Razavi , Soudeh Berahmand , Khalil Sarikhani Khorami , Motahareh Kaboodsaz Yazdi, Nasim Namiranian ,
Volume 7, Issue 3 (9-2019)
Abstract
Background and objectives: An effective factor in choosing the correct place for the dental implant and performing surgical procedures in the posterior regions of mandible is the position of the mandibular canal. Failure to consider this important landmark will damage the inferior alveolar nerve. Considering the widespread use of implants and the precision of the images obtained from CBCT. The aim of this study was to evaluate the rate of visibility of mandibular canal by CBCT in order to prevent damage to the inferior alveolar nerves and arteries.
Material And Methods: In this study, 90 archived CBCT images of patients from a private center of oral and maxillofacial radiology in Yazd that was taken by technician was evaluated during 2012-2019. The visibility of the mandibular canal in reconstructed panoramic images of CBCT was assessed by a dentistry student trained by the maxillofacial radiologist in five areas in different thicknesses on each side. Data were analyzed using SPSS 17 software. Chi-square, and correlation coefficient were done.
Results: In total, in 53.38% of CBCT images both borders of mandibular canal were visible, in 17.95%, only one border was visible (difficult observation) and in 28.7% of cases, lack of visibility of mandibular canal was reported. There was no significant difference between sex, age, side and thickness in mandibular canal visibility (P >0.05).
Conclusion: In more than half of CBCT images, both borders were clearly visible in both right and left sides; therefore we can conclude that CBCT is a useful tool for the observation of mandibular canal before surgeries.
Khalil Sarikhani Khorami , Fatemeh Ezoddini Ardakani , Yaser Safi , Motahare Baghestani,
Volume 7, Issue 3 (9-2019)
Abstract
Background and objectives: The retromolar canal is an anatomical variant that needs consideration in local anesthesia and surgical procedures involving the retromolar area. Complications such as local anesthetic insufficiency, a sensory deficit, hemorrhage and traumatic neuroma may arise in the absence of recognition of these variants. The aim of this study is to determine the prevalence and course of retromolar canal in the Iranian population.
Methods: This study is a descriptive cross sectional study. The cross sectional sagittal and three dimensional images from volumetric CBCT. data of 270 patients were reconstructed using on demand imaging analysis software. Retromolar canals were classified into two types according to the courses. The width and location (distance from the third molar) of retromolar canals were evaluated. Results were analyzed with SPSS 20 software and were assessed using the t_test and chi_square test.
Results: Retromolar canal was observed in 9/25 % of patients. The mean width of the retromolar foramen was 1/43 mm, and the mean distance from anterior border of retromolar foramen to the distal CEJ of the second molar was 13/33 mm.
Conclusion: The prevalence of retromolar canals in the Iranian population was lower than that was reported in previous studies. It can be observed in 9/25 % of Iranian patients. Damage to the retromolar canal may be unavoidable during surgical procedures may result in paresthesia, excessive bleeding, postoperative hematoma, or traumatic neuroma. Therefore, the clinician must pay particular attention to the identification of a retromolar canal by preoperative radiographic examination and additional CBCT scanning is recommended.
Saeed Mohammadi,
Volume 7, Issue 4 (12-2019)
Abstract
Aryl hydrocarbon receptor (AHR) signaling has been introduced to be involved in macrophages polarization. The perturbation of AHR has been reported in hypoxia and related disorders. Here, I would like to highlight the significance of AHR in hypoxia-mediated macrophages polarization and suggest conducting further experiments on related subjects.
Farzaneh Mirhoseini, Motahare Baghestani, Mohammad Hadi Khajezade, Ali Derafshi, Motahareh Kaboodsaz Yazdi,
Volume 7, Issue 4 (12-2019)
Abstract
Background and objective: Accurate understanding of the anatomy of the inferior alveolar nerve (IAN) and its relation with anatomical landmarks of mandibular molar teeth can reduce the risk of unwanted injuries to the IAN during implant placement.
Methods: 44 CBCTs of patients,who have been reffered to the private oral and maxillofacial radiology center, were examined by a radiologist on the axial, sagittal and coronal planes. Then, the distances between mandibular canal and buccal cortex (BN) and lingual cortex (LN), buccolingual width of the mandibular canal (BL), and the distances between the canal and apex of the first molar (M1N) and second molar of mandible (M2N) were obtained from cross-sectional images. Data were analyzed using SPSS17 software and Kolmogorov-smirnov and Mann-whitney test.
Results: 21 males and 23 females aged 20 to 50 years old (mean age: 37.8±7.52) were examined. The mean intervals in the regions of first molar in the right and left sides were BN: 4.03,4.06 mm, LN: 2.10,2.58 mm, BL: 2.20,2.20 mm, and M1N: 5.77,5.78 mm and in the second molar region, on the right and left sides were BN: 5.21,5.20 mm, LN: 1.95,1.80 mm and BL: 2.30,2.20 mm and M2N: 3.85,3.55 mm, respectively. There was a significant difference in the mean buccolingual width of mandibular canal in both sides in the region of first molar and left side in the region of second molar between two genders. (P=0.009, P=0.019, P=0.045). Other measurements were not significantly different between two genders (P>0.05). The age range of patients had no effect on any of the distances and measurements (P>0.05).
Conclusion: buccolingual width of mandibular canal in both sides in the region of first molar and left side in the region of second molar was associated with gender.
Zinab Shykholeslami, Ahmad Abdi, Alireza Barari, Seyed Ali Hosseini,
Volume 7, Issue 4 (12-2019)
Abstract
Background and objectives: Proper nutrition and exercise are two effective factors in improving liver function in old age. The aim of this study was to investigate the effect of aerobic training (T) with consumption of Citrus aurantium (CA) on SIR1 and PGC-1α gene expression levels in the liver tissue of elderly rats.
Method: In this experimental study, 25 elderly female rats were placed in five groups of 5 rats, including 1) control, 2) sham, 3) CA, 4) T and 5) T+CA. Over the course of eight weeks, groups 4 and 5 ran on the treadmill three sessions per week at 65 to 75 percent of the maximum running speed, and groups 3 and 5 received 300 mg/kg/day of CA extract peritoneally. Forty- eight hours after the last training session and CA consumption, SIR1 and PGC-1α gene expression levels in the liver tissue were measured by real-time PCR method. In order to analyze the findings, the Shapiro-Wilk, one-way ANOVA with Tukey’s post- hoc tests were used (P≤0.05).
Results: T had a significant effect on increasing SIR1 (P = 0.009) and PGC-1α (P = 0.001) gene expression levels; CA had a significant effect on reducing SIR1 gene expression levels and increasing PGC-1α (P = 0.001); T + CA had a greater effect on increasing PGC-1α gene expression levels than T and CA (P = 0.001).
Conclusion: Although eight weeks of T and CA consumption alone appear to improve PGC-1α gene expression levels in the liver tissue of elderly rats, concurrent T and CA consumption has more favorable effects than each of them alone.
Masoud Esmaeili, Negin Khosravi, Ali Habibi Kia,
Volume 8, Issue 2 (7-2020)
Abstract
Background: Supernumerary teeth are known as the teeth in excess of the normal dentition. Multiple supernumerary teeth are usually observed as having syndromes. Conversely, multiple supernumerary teeth without any associated systemic conditions or syndromes are not common.
Case presentation: This article documents an unusual case report, a male patient with non-syndromic 10 supernumerary teeth in both jaws, an incidental finding during routine radiographic examination.
Conclusion: CBCT is the best diagnostic imaging method currently available for determining the relationships of teeth and the surrounding structures in cases with multiple impacted teeth or severe overlapping of impacted teeth.
