Showing 45 results for Mir
Seyed Hossein Razavi , Soudeh Berahmand , Khalil Sarikhani Khorami , Motahareh Kaboodsaz Yazdi, Nasim Namiranian ,
Volume 7, Issue 3 (9-2019)
Abstract
Background and objectives: An effective factor in choosing the correct place for the dental implant and performing surgical procedures in the posterior regions of mandible is the position of the mandibular canal. Failure to consider this important landmark will damage the inferior alveolar nerve. Considering the widespread use of implants and the precision of the images obtained from CBCT. The aim of this study was to evaluate the rate of visibility of mandibular canal by CBCT in order to prevent damage to the inferior alveolar nerves and arteries.
Material And Methods: In this study, 90 archived CBCT images of patients from a private center of oral and maxillofacial radiology in Yazd that was taken by technician was evaluated during 2012-2019. The visibility of the mandibular canal in reconstructed panoramic images of CBCT was assessed by a dentistry student trained by the maxillofacial radiologist in five areas in different thicknesses on each side. Data were analyzed using SPSS 17 software. Chi-square, and correlation coefficient were done.
Results: In total, in 53.38% of CBCT images both borders of mandibular canal were visible, in 17.95%, only one border was visible (difficult observation) and in 28.7% of cases, lack of visibility of mandibular canal was reported. There was no significant difference between sex, age, side and thickness in mandibular canal visibility (P >0.05).
Conclusion: In more than half of CBCT images, both borders were clearly visible in both right and left sides; therefore we can conclude that CBCT is a useful tool for the observation of mandibular canal before surgeries.
Farzaneh Mirhoseini, Motahare Baghestani, Mohammad Hadi Khajezade, Ali Derafshi, Motahareh Kaboodsaz Yazdi,
Volume 7, Issue 4 (12-2019)
Abstract
Background and objective: Accurate understanding of the anatomy of the inferior alveolar nerve (IAN) and its relation with anatomical landmarks of mandibular molar teeth can reduce the risk of unwanted injuries to the IAN during implant placement.
Methods: 44 CBCTs of patients,who have been reffered to the private oral and maxillofacial radiology center, were examined by a radiologist on the axial, sagittal and coronal planes. Then, the distances between mandibular canal and buccal cortex (BN) and lingual cortex (LN), buccolingual width of the mandibular canal (BL), and the distances between the canal and apex of the first molar (M1N) and second molar of mandible (M2N) were obtained from cross-sectional images. Data were analyzed using SPSS17 software and Kolmogorov-smirnov and Mann-whitney test.
Results: 21 males and 23 females aged 20 to 50 years old (mean age: 37.8±7.52) were examined. The mean intervals in the regions of first molar in the right and left sides were BN: 4.03,4.06 mm, LN: 2.10,2.58 mm, BL: 2.20,2.20 mm, and M1N: 5.77,5.78 mm and in the second molar region, on the right and left sides were BN: 5.21,5.20 mm, LN: 1.95,1.80 mm and BL: 2.30,2.20 mm and M2N: 3.85,3.55 mm, respectively. There was a significant difference in the mean buccolingual width of mandibular canal in both sides in the region of first molar and left side in the region of second molar between two genders. (P=0.009, P=0.019, P=0.045). Other measurements were not significantly different between two genders (P>0.05). The age range of patients had no effect on any of the distances and measurements (P>0.05).
Conclusion: buccolingual width of mandibular canal in both sides in the region of first molar and left side in the region of second molar was associated with gender.
Samira Mahmoudi, Rozita Nasiri, Abolfazl Jafari Sales,
Volume 7, Issue 4 (12-2019)
Abstract
Background and objectives: Microbial resistance to antibiotics is one of the most common problems in the health care system. Therefore, many efforts have been performed to find new compounds as antimicrobial compounds. This study carried out to investigate the in-vitro antibacterial effect of methanolic extract of peppermint on standard Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa strain.
Material and Methods: In this experimental laboratory study, after collecting and performing pharmacognosy evaluations, methanolic extract of the peppermint plant was prepared and its antimicrobial effects on several bacteria were determined at concentrations of 20 to 400 mg/ml using the agar well diffusion method, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) methods. The test was repeated five times for each bacterium and the collected data were analyzed using SPSS software.
Results: It was revealed that the methanolic extract of peppermint had antimicrobial effects against standard Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. The highest effect was observed in S. aureus and the least in P. aeruginosa. MIC and MBC of methanol extract on S. aureus, B. cereus, E. coli, and P. aeruginosa were 6.5-15.5, 15.5-25, 50-100, and 100-200 mg/ml, respectively.
Conclusion: The results of this study reveal that peppermint can be considered as an antibacterial medicinal herb and that if the concentration of the extract is higher, its antibacterial properties will also increase. Thus, it can be used as an alternative to the usual chemical drugs in the treatment of infections after evaluating their effects in vitro.
Fatemeh Monirian, Reyhane Abedi, Negar Balmeh, Samira Mahmoudi, Fereshteh Mirzaei Poor,
Volume 8, Issue 3 (10-2020)
Abstract
Background and objective: Some common problems in the health care system are Microbial resistance to antibiotics, the side effects of food additives, and preservatives. Considering the antibiotic resistance of microorganisms and the need to identify new compounds, the present study was conducted to determine the antimicrobial effects of Artemisia extracts.
Material And Method The study was performed in two stages including extraction and determination of antibacterial properties of aqueous, ethanolic, methanolic, acetone/ethanolic, and hydroethanolic extracts of Artemisia on standard Pseudomonas aeruginosa, Streptococcus pyogenes, and oral bacteria sample. The well diffusion method was performed to evaluate the concentration that had an inhibitory and bactericidal effect.
Result: Aqueous extract had an effect on the oral bacteria sample (8 mm), the methanolic extract had an effect on S. pyogenes and oral bacteria sample (15 mm) and finally acetone/ethanolic extracts had antimicrobial properties against S. pyogenes (16 mm). The concentration used for all five extracts was 50 mg/ml and showed an inhibition effect on the growth of S. pyogenes standard strain and oral bacteria sample. The less serial dilutions of extracts were tested but no antibacterial effects were seen. So, 50 mg/ml was the minimum concentration that had an inhibitory and bactericidal effect.
Conclusion: It can be inferred that aqueous, methanolic, and acetone/ethanolic extracts of Artemisia had the highest inhibitory effect on S. pyogenes and the oral bacteria sample. Consequently, by applying different extraction methods and by utilizing different solvents, it may be possible to more efficiently obtain biomaterials with antimicrobial properties from this plant.
Mostafa Yeganegi, Ali Behnampour, Fatemeh Mirzaei, Atena Tabrizi, Haleh Zokaee,
Volume 8, Issue 4 (12-2020)
Abstract
Background and objective: Psychological status is one of the quality of life (QOL) domains which can be affected by hyposalivation caused by head and neck radiotherapy. This study aimed to evaluate the psychological status of head and neck cancer (HNC) patients who were suffering from hyposalivation after at least one week of receiving radiotherapy.
Material And Methods: This descriptive-analytic study was performed on 44 HNC patients with history of hyposalivation caused by radiotherapy, in 5 Azar hospital from 1397-1398. General Health Questionnaire (GHQ-28) was used for data collection. Shapiro-Wilk test, parametric and nonparametric tests and SPSS 18 software were used for statistical analysis.
Results: The average psychological status of patients was 27.50 out of 84 (lower score indicated better psychological status). The mean score of physical health was 7.39, social functioning was 6.16, anxiety/insomnia were 12.64 and depression was 1.33 with the maximum being 21. Psychological status was not significantly different between genders. Ageing caused all subscales to increase except depression. A direct relationship between social functionality and psychological status was reported.
Conclusion: Hyposalivation due to radiotherapy affects psychological status and its components in patients. Also, various factors such as ageing and lower education level can be effective in reducing psychological status in the patients with head and neck cancer who were suffering from hyposalivation due to receiving radiotherapy.
Fakhrosadat Hashemi, Farshad Tojari, Hamid Sajjadi Hezave, Abdolreza Amirtash,
Volume 9, Issue 1 (3-2021)
Abstract
Background and Objective: Research on how to participate in recreational sports and the factors influencing the choice of these sports are too meager in health areas. Therefore, the aim of this study was to analyze the effect of recreational sports development on health and Participation of students in sports activities.
Material and Methods: The present study is descriptive-correlative in terms nature, and is applied in terms of purpose. The statistical population of the study consisted of all university students in Bushehr city, from whom the study sample was picked based on stratified random selection (N=384). To collect data, a researcher-made questionnaire was used and the validity of the questionnaire was confirmed by twelve experts. Also, its reliability was calculated using Cronbach's alpha (r=0.91) and composite reliability. In order to analyze the data and examine the fit of the model, structural equation modeling was implemented using PLS3 and SPSS24 software (p≤0.05). The results of path analysis revealed that the development of recreational sports has a direct and positive correlation with physical health. Also, the effect of recreational sports development on students’ participation in sport was significant.
Results: The results of factor analysis showed that physical health, mental health, and physical fitness had a significant role in explaining the physical health variable. Also, social aspects, athletic interest and pleasure, athletic performance and athletic skill acquisition had a determining role in the sport participation variable.
Conclusion: According to the findings, it can be deduced that in the attention to and research on sport participation in health area, simply reliance on individual characteristics results in Halo error (based on behavioral theories), and to avoid it, it’s better to notice the effects of other variables, such as the athletic interest and pleasure, athletic performance, and athletic skill-acquisition.
Ghadir Sohrabi, Mahdi Malmir, Ali Asghar Ghafarizade, Tayebeh Faraji,
Volume 9, Issue 1 (3-2021)
Abstract
Background and Objective: Downscale outcome in assisted reproductive techniques (ART) is associated with lipid peroxidation. Melatonin may have beneficial effects against lipid peroxidation and oxidative stress. This work was aimed to evaluate the ameliorative capacity of melatonin versus the passage of time and lipid peroxidation on sperm parameters from the men with ATS in the ART process.
Material and Methods: Semen samples were collected from 50 asthenoteratozoospermic (ATS) men. Samples were divided into control and melatonin group. The test group were incubated with 6 mM melatonin at 2, 4, 6, and 24 hours. Then total and progressive motility, membrane integrity, and Malondialdehyde levels (MDA) were evaluated. Statistical analysis was carried out by SPSS software (repeated-measures ANOVA).
Results: In the control group, total (p<0.01) and progressive (P<0.05) motility and also, membrane integrity (P<0.03) significantly decreased although, MDA levels of sperm significantly increased (*P<0.04). Moreover, in the melatonin group, the mentioned parameters significantly compensated compared to the control group (P<0.05).
Conclusion: In the outcome, melatonin in vitro treatment paves the way for motility and membrane integrity up-regulating in the ATS men.
Farah Nameni, Samira Falahi,
Volume 9, Issue 3 (10-2021)
Abstract
Background and Objective: Alzheimer's disease is a common cause of dementia and reduces progressive perception, memory, and tasks. This study aimed was to investigate the effects of interval training and octopamine extract on NLRP-1 and NLRP-3 in brain tissue of rats with Alzheimer's disease.
Material and Methods: The research method was experimental with a post-test design. A total of 42 male Wistar rats, all of which were eight weeks old, were obtained. Rats were randomly divided into 5 groups (healthy control, Alzheimer's sham, Alzheimer's+ interval training, Alzheimer's+ octopamine supplementation, Alzheimer's+ interval training+ octopamine supplementation). Alzheimer's induction was performed with beta-amyloid peptide 1-14. The training protocol was intense periodic. Octopamine was supplemented by intra-peritoneal injection. Morris's blue maze test was used for the spatial memory test. Seventy-two hours after the last training session, anesthetized rats and hippocampus were quickly extracted. A one-way ANOVA test was used to estimate intergroup differences after Alzheimer's induction.
Results: The results of one-way ANOVA showed a significant difference between the groups in NLRP-1 and NLRP-3 mRNA. Bonferroni test confirmed significant between the control group and Alzheimer's groups (P≤0.05).
Conclusion: The changes were considered to be synergistic of the beneficial effects of physical activity and octopamine in preventing or reducing the harmful effects of pathological conditions. Exercise and supplementation seem to be effective in the relationship between inflammatory and neurotrophic factors in neurological disorders.
Fahimeh Hosseinabadi, Tayebeh Faraji, Mahdi Malmir,
Volume 9, Issue 4 (12-2021)
Abstract
Background and Objective: Quercetin is a polyphenolic flavonoid compound with a potent antioxidant impact, proposed to make a drastic contribution in treating male infertility. The current systematic review aimed to provide an overview of previous studies about quercetin's impact on male infertility.
Material and Methods: Electronic search with MeSH words including Quercetin, Infertility, Sperm, Testicular tissue, and Sex hormones was accomplished in databases Web of Science, Scopus, Science Direct, Wiley, NCBI, and Google Scholar. Finally, 296 articles were recognized during the primary search. A total of 144 papers,passing the analysis stage containing Identification, Screening, and Eligibility were selected for assessment.
Results: Quercetin prevents damage to the testicular germinal epithelium and facilitates the spermatogenesis process by strengthening the antioxidant system, reducing lipid peroxidation and oxidative stress, preventing the expression of pro-apoptotic genes, increasing testosterone and gonadotropins.
Conclusion: In conclusion, the present review showed that quercetin by its antioxidant impacts, can counteract various toxins that induce oxidative stress in the male reproductive system.
Nazila Javadi-Pashaki, Mohammad Javad Ghazanfari, Sahar Miri , Samad Karkhah,
Volume 9, Issue 4 (12-2021)
Abstract
Decreased life expectancy is considered as a key indicator of human development. Obviously, the increase in mortality, especially in vulnerable groups such as older people, leads to a major disruption in the human development of countries. On the other hand, the destructive social and economic effects of COVID-19 on human life further reduce their life expectancy. Therefore, it is suggested that policymakers and health managers make appropriate decisions such as timely vaccination of older people, future treatment measures, and appropriate behavioral changes to control the disease and improve life expectancy among older people during the COVID-19 pandemic.
Sahar Miri, Samad Karkhah, Pooyan Ghorbani Vajargah, Amirabbas Mollaei, Atefeh Falakdami, Poorya Takasi, Amir Emami Zeydi, Mohammad Javad Ghazanfari,
Volume 10, Issue 1 (3-2022)
Abstract
Background and Objective: Since December 2019, the widespread outbreak of COVID-19 has led to a major public health issue worldwide. With the spread of the COVID-19 pandemic, a series of ethically challenging issues arose that put pressure on healthcare systems around the world. This narrative review aims to comprehensively review the literature focusing on ethical challenges and coping strategies about issues related to the healthcare system and social issues during the COVID-19 pandemic.
Material and Methods: This narrative review was conducted via international databases including PubMed/MEDLINE, Web of Science, and Scopus using keywords extracted from medical subject headings such as "COVID-19", "2019-nCoV disease", "2019 novel coronavirus infection", "Ethics", "Bioethical Issues", "Morals", "Coping Skills", "Coping Skill", "Coping Strategies", and "Coping Strategy" from December 2019 to January 2022.
Results: In general, ethical issues during the COVID-19 pandemic can be divided into two categories: 1) issues related to the healthcare system and 2) social issues. Issues related to the healthcare system can be divided into two categories: 1) lack of resources, equipment and facilities, and manpower, and 2) problems in patient care such as triage and informed consent. Social issues can be divided into four categories: 1) community engagement, 2) crisis management capacity in remote rural communities, 3) discrimination and health equity, and 4) vaccination. Coping with ethical challenges in crises such as COVID-19 requires changing health empowerment policies and strategies based on evidence-based research. On the other hand, overcome on these challenges requires interdisciplinary collaboration and fast efficient decisions.
Conclusion: Overall, the present study introduced ethical challenges and coping strategies during the COVID 19 pandemic. The experience gained from this pandemic can be considered by managers and policymakers of health care systems for coping with ethical challenges.
Fahimeh Hosseinabadi, Tayebeh Faraji, Mahdi Malmir, Hanieh Mohamadi,
Volume 10, Issue 2 (5-2022)
Abstract
Background and objectives: Numerous studies have evaluated the effects of silymarin on sperm quality and its neutralization impact of various toxins on the male reproductive system. However, these studies as a whole have not been summarized and categorized yet. Silymarin is a flavonoid and known as a powerful antioxidant compound in the treatment of many diseases including liver disorders, rhinitis, diabetes, and testis disorders. The aim of the study was to discuss the impact of silymarin on the male reproductive system.
Material and Methods: From Apr 1998 to Feb 2020, related articles were extracted from databases of Web of Science (WOS), PubMed, Google Scholar, Science Direct, Scopus, EBSCO and grey literature by seeking MeSH words including Silymarin, Milk thistle, Silybum marianum, testis, Spermatogenesis, and Sex hormones.
Results: Silymarin withholds damage to the testicular germinal epithelium and comforts the spermatogenesis process by amplification the antioxidant system, decrease lipid peroxidation and oxidative stress, preventing the expression of pro-apoptotic genes, increases testosterone and gonadotropins.
Conclusion: In outcome, based on the results, silymarin can boost fertility in sterility males by its talented antioxidant features.
Aliakbar Naghavialhosseini, Mina Pakkhesal, Maryam Ghelichli, Amir Reza Ahmadinia,
Volume 10, Issue 3 (10-2022)
Abstract
A Dentigerous Cyst (DC) is the most common developmental odontogenic cyst that mostly happens in patients between 10 to 30 years of age. It is usually completely asymptomatic and is discovered on a routine radiographic examination or to evaluate the reason for an erupted tooth. Radiographically, this cyst usually presents a well-defined unilocular radiolucency attached to CEJ of an unerupted tooth which can cause displacement of adjacent tooth or resorption.
This article reports a large infected DC in a 10-year-old male patient related to first and second premolar maxillary teeth, which did not erupt or even change their positions. DC was treated successfully by decompression. After 2 years follow up, there was no evidence of recurrence. In conclusion, marsupialization of cyst with no orthodontic intervention or tooth extraction is a conservative, efficient protocol that stimulates bone healing and promotes the eruption of unerupted teeth even if they are deeply crowded.
Nazila Javadi-Pashaki, Hamidreza Mehrabi, Iman Asdaghijahromi , Seyedeh Mahjabin Taheri Otaghsara, Mohammad Javad Ghazanfari, Pooyan Ghorbani Vajargah, Amirabbas Mollaei, Atefeh Falakdami, Poorya Takasi, Aghil Mollaei, Hatef Mashhadi, Samad Karkhah,
Volume 10, Issue 3 (10-2022)
Abstract
Background and Objectives: The implementation of Complementary and Alternative Medicine (CAM) has increased in recent decades. Due to the positive effects of CAM interventions, 5 to 74.8% of people use these treatments worldwide. However, implementing CAM-related clinical trials is associated with challenging issues. Failure to address these challenges can lead to poor quality of studies, publication of non-scientific findings, and ultimately disregard for human rights and ethics. This review aims to comprehensively review the literature focusing on methodological and ethical challenges for implementing CAM-related clinical trials.
Material and Methods: This review of reviews was conducted via international databases, including PubMed/MEDLINE, Web of Science, and Scopus using keywords extracted from medical subject headings such as “Methods”, “Methodological Study”, “Methodological Studies”, “Ethics”, “Complementary Therapies”, “Complementary Medicine”, “Alternative Medicine”, “Clinical Trial”, and “review” from the earliest to May 1, 2022.
Results: In general, challenging issues for the implementation of CAM-related clinical trials can be divided into two categories: 1) methodological and 2) ethical. Methodological challenges included: Risk of bias, Lack of knowledge of researchers, and Blinding. On the other hand, ethical challenges in clinical trial studies are divided into two categories: patients' rights and placebo use.
Conclusion: Overall, the present study emphasizes the need for special attention to the quality of CAM-related clinical trials. Also, this study can pioneer the introduction of critical challenging issues in CAM-related clinical trials and provide appropriate suggestions for researchers to solve these issues in future studies.
Mohammad Javad Ghazanfari, Raziyeh Chaghian Arani, Amirabbas Mollaei, Aghil Mollaei, Atefeh Falakdami, Poorya Takasi, Pooyan Ghorbani Vajargah, Shaqayeq Esmaeili, Hedayat Jafari, Tahereh Yaghoubi, Samad Karkhah,
Volume 10, Issue 3 (10-2022)
Abstract
Background and Objectives: High workload, insufficient resources, and many stressors in the workplace have led to the imposition of physical and psychological pressures on nurses, which exposes them to death anxiety (DA). This systematic review aimed to assess the DA and factors associated with its in nurses during the COVID-19 pandemic.
Material and Methods: An extensive search was conducted on Scopus, PubMed, Web of Science, Iranmedex, and Scientific Information Database (SID) databases via keywords such asincluding "Death", "Death Anxiety", "Nurses", and "COVID-19", from December 2019 to November 10, 2021.
Results: 818 nurses were enrolled in four papers. The mean age and work experience of nurses Nurses’ mean age and work experiences were 31.21 (SD=5.43) and 7.60 (SD=6.73) years, respectively. The mean DA of nurses during the COVID-19 pandemic was 7.30 (SD=2.23). Also, 31.05% of nurses had a high level of DADA level during the COVID-19 pandemic. Age, sex, work experience, working hours per week, childbearing, several patients needing end‑of‑life care, direct participation in resuscitation operations, cases of direct participation in resuscitation operations, cases of patient death, depression, mental health status, and life satisfaction were influential factors in DA nurses during the COVID-19 pandemic.
Conclusion: Thus, nursing policymakers should pay special attention to these factors related to the use of nurses' health maintenance and promotion programs to increase the quality of nursing care for COVID-19 patients. Also, it is recommended that psychological and communication support be provided to nurses during the COVID-19 pandemic.
Seyed Rafie Shafabakhsh, Yaser Kazemzadeh, Hossein Shirvani, Sanaz Mirzaiyan Shanjani, Saeed Sedaghati,
Volume 11, Issue 1 (7-2023)
Abstract
Background: Skeletal muscle is a tissue that secretes myokines from muscle cells in response to training stimuli and muscle contractions. Therefore, this study aimed to investigate the effect of 4-week moderate-intensity aerobic exercise on the expression of three genes: apelin, decorin, and musclin in the skeletal muscle fibers of Wistar rats. In addition, the study examined the changes in gene expression levels during the training period.
Methods: The present study enrolled 16 male Wistar rats with an approximate age of eight weeks and a weight range of 200-220 grams. They were randomly divided into two equal groups: An aerobic exercise group (n=8) and a control group (n=8). During the four-week training period, the experimental group performed aerobic exercises on a treadmill with an intensity of 50-70% of their maximum power, for three sessions per week, while the control group did not engage in any activity. After completing the training period, the rats were sacrificed 48 hours later to evaluate the gene expression of the study variables using the real-time PCR method for tissue analysis. An independent t-test was used to examine the difference between groups, and statistical significance was set at P <0.05.
Results: The independent t-test results indicated that the gene expression levels of all three variables: Musclin, decorin, and apelin, were significantly higher in the aerobic exercise group compared to the control group.
Conclusion: The study findings suggest that aerobic exercise can potentially to increase the gene expression of three specific myokines: apelin, decorin, and musclin in skeletal muscles. These myokines are known to play an essential role in energy homeostasis, and their increased expression levels could have potential health benefits for individuals engaged in aerobic exercise.
Fatemeh Mirzaei Ashrafi, Seyed Mohsen Avandi, Ali Khaleghian,
Volume 11, Issue 1 (7-2023)
Abstract
Fatemeh Mirzaei Ashrafi 
, Seyed Mohsen Avandi , Ali Khaleghian
Background: Obesity has become a significant health concern in recent decades, characterized by increased body fat. This study aimed to compare the effects of circuit and traditional resistance training on serum calprotectin levels in obese men.
Methods: A pre-test-post-test design was used with thirty-three sedentary young obese men (age 21.33±2.49 years, weight 92.23±14.39 kg and BMI 30.71±4.63 kg/m²) who were randomly divided into two groups: experimental and control. The experimental group underwent a 12-week periodized resistance training program consisting of three sessions per week, gradually increasing in intensity from 50% to 80% of their one-repetition maximum (1RM) using a wave pattern. Resting serum calprotectin levels were measured before and after the intervention. Data were analyzed using analysis of variance (ANOVA) and paired sample t-tests, with statistical significance at p < 0.05.
Results: Both periodized circuit and traditional resistance training resulted in increased plasma levels of calprotectin compared to the control group (p = 0.001). Additionally, the periodized circuit resistance training group demonstrated a greater increase in plasma levels of calprotectin than the traditional resistance training and control groups (p = 0.01).
Conclusion: These findings suggest that twelve-week periodized circuit and traditional resistance training programs can effectively increase calprotectin levels in obese men.
Samira Naderi Noreini, Roya Ahmadi Nia Tabesh, Mahdi Malmir, Ali Asghar Ghafarizade,
Volume 11, Issue 2 (10-2023)
Abstract
Background: Sperm preparation is a time-consuming process that makes a contribution to oxidative stress induction in assisted reproductive techniques.
Objective: This study aimed to evaluate the effect of L-carnitine on sperm parameters during semen preparation at different time intervals.
Materials and Methods: In this in vitro study, the semen samples of 50 asthenoteratozoospermic men were divided into the control and the L-carnitine groups (incubated with 0.5 mg/mL L-carnitine) (n=25/each). Total motility, progressive motility, sperm membrane integrity (by Hypo-osmotic swelling test), and lipid peroxidation (by Malondialdehyde level) were assessed in each group after 2, 4, and 6 hours. Afterward, samples were analyzed by the World Health Organization (2010) criteria.
Result: The results showed that in the control group total and progressive motility, and membrane integrity of the sperm were significantly decreased after 2 hr (P= 0.028, p= 0.019, and p= 0.025, respectively), while Malondialdehyde levels increased significantly after 4 hr (P= 0.018). Sperm parameters in the L-carnitine group increased significantly after 2 hr (P= 0.002), while Malondialdehyde levels decreased significantly compared to the control group in 6 hr (P < 0.001 vs. P =0.045).
Conclusion: Based on these results, L-carnitine can manage to conserve motility and sperm membrane integrity of sperm from the hazardous impact of oxidative stress and lipid peroxidation during sperm preparation.
Amir Abbas Barzegari, Ahmad Aghaee, Kamran Shahabi,
Volume 11, Issue 2 (10-2023)
Abstract
Background: Promising results were obtained by using medicinal plants for the treatment and prevention of opioid withdrawal syndrome. A native Iranian plant, Echinophora platyloba, has shown analgesic effects that may be mediated through opioid receptors. Thus, the present research evaluated the effects of the ethanolic extract of E. platyloba on the acquisition of morphine dependence in mice.
Methods: Thirty-two male mice were randomly allocated into four groups of eight. Morphine dependence was induced in the mice by subcutaneous administration of morphine (50, 50, and 75 mg/kg)×3 days, plus a single dose of morphine (50 mg/kg) on the fourth day. Withdrawal syndrome was precipitated by intraperitoneal injection of naloxone (4 mg/kg) 2 hours after the last dose of morphine. On days of dependence induction and before each morphine dose, the mice received intraperitoneal injections of saline (10 ml/kg) or plant extract (25, 50, and 75 mg/kg). After the injection of naloxone, the symptoms of withdrawal syndrome in each animal were monitored for 30 minutes.
Results: Administering morphine with this method induced morphine dependence in mice that were treated with saline before morphine. However, the mice that received the plant extract showed a significant decrease in the withdrawal symptoms including the number of jumping (P<0.01), rearing (P<0.05), grooming (P<0.05), and diarrhea (P<0.01) compared with the saline-treated mice.
Conclusion: Administration of the hydro-ethanolic extract of E. platyloba before morphine may inhibit the induction of morphine dependence. Therefore, the plant extract may be considered a therapeutic agent for the prevention of morphine dependence in morphine users.
Hamid Reza Zolfi, Amir Shakib, Zahra Niknam, Zhaleh Pashaei,
Volume 11, Issue 3 (12-2023)
Abstract
Background: Metabolic syndrome, a problem of the present age, is a combination of several medical issues, and miRNAs play important regulatory roles in metabolic syndrome. Many studies indicate that high-intensity interval training (HITT) may improve risk factors for metabolic syndrome.
This study aimed to investigate the effect of 8 weeks of HIIT training on the changes in miR-21, miR-122, alanine aminotransferase (ALT), aspartate aminotransferase (AST), low-density lipoprotein (LDL), lipid profile, and glucose.
Methods: In this quasi-experimental study, middle-aged male (n=19) volunteers with metabolic syndrome (body mass index (BMI)>30) were randomly assigned to the control (n=9) and training (n=10) groups. The training program consisted of 8 weeks of HIIT training with 4 sets of workouts with an intensity of 80-90% heart rate for the training group (3 sessions per week during the first 4 weeks and 4 sessions per week during the second 4 weeks). Blood samples were collected from the subjects 48 hours before and after the last training session to analyze miR-21, miR-122, ALT, AST, HDL, LDL, triglyceride, cholesterol, and glucose. The within-group and between-group differences of data were analyzed using the paired t-tests and analysis of covariance at a significance level of P˂0.05 in SPSS software.
Results: This study indicated that HIIT caused a significant decrease in miR-122, ALT, AST, triglyceride, cholesterol, glucose, body weight indicators, fat percentage, and BMI (P˂0.05). Also, a significant increase in miR-21 and HDL levels was observed following HIIT training (P˂0.05).
Conclusion: HIIT training seems essential in metabolic changes, such as reducing the lipid profile, decreasing glucose, and improving liver damage by affecting miR-21 and miR-122 indicators as small regulatory transcripts. However, more extensive studies are needed in this field.
