Showing 45 results for Mir
Elmira Farmanbordar, Mohammad Taghi Badeleh Shamushaki ,
Volume 11, Issue 3 (12-2023)
Abstract
Background: Body image studies confirm a higher level of dissatisfaction among women compared to men, and some evidence shows that ethnicity may have a role in the level of body image fear.
Methods: In this cross-sectional study, the data of 372 Fars and Turkmen women visiting health care centers in Gonbad, Iran, were collected via convenience sampling and analyzed by SPSS v. 17. The instruments were a demographic checklist and Littleton's Body Image Concern Inventory.
Results: The level of fear of body image between Fars (M = 2.022, SD = 0.685) and Turkmen (M = 2.1408, SD = 0.661) ethnicities was not statistically different (P-value = 0.09) based on the t test. Furthermore, age, education level, and internet usage were significantly related to the variable of fear of body image.
Conclusion: The role of ethnicity in the fear of body image is not statistically significant and needs further research.
Samaneh Heidarzadeh, Seyedehsamira Ashrafmansouri,
Volume 11, Issue 4 (12-2023)
Abstract
Background: Gastric cancer is the fifth most common neoplasm and the fourth leading cause of mortality worldwide. Incidence rates vary widely and depend on risk factors, epidemiological factors, and carcinogenesis patterns. Understanding the molecular mechanisms underlying cancer progression and metastasis is crucial for developing effective therapeutic strategies. Previous studies have reported that fascin overexpression, an actin-binding protein, promotes cell motility and invasion in cancers by bundling actin filaments. Therefore, inhibiting this protein can be a major step in treatment.
Methods: In this prospective study, the protein structure of fascin was obtained from the Protein Data Bank (PDB). Using the HyperChem 7.0 software, the chemical structure of cytochalasin H as a small molecule inhibitor was designed. Rigid docking studies between cytochalasin H and fascin protein were performed using the AutoDock Vina 1.1.2 software, and the obtained results were analyzed using LigPlot+ v.1.4.5, Discovery Studio 4.5, and PyMOL v.1.9 software.
Results: According to the analyses and the obtained results, cytochalasin H and fascin protein have an effective interaction with an optimal energy level.
Conclusion: These findings suggest that cytochalasin H may be developed into a potential chemotherapeutic drug for the treatment of gastric cancer by inhibiting fascin. Nevertheless, further in vitro and in vivo experiments are necessary to elucidate the exact mechanism.
Malihe Bakhti, Farzaneh Taghian, Khosro Jalali Dehkordi , Rezvan Mirsafaei Rizi,
Volume 12, Issue 3 (12-2024)
Abstract
Background: Hypothyroidism is typically associated with a decreased basal metabolic rate, reduced energy expenditure, and weight gain. Exercise training and Dorema Aucheri (DA) have been identified as beneficial therapeutic strategies within complementary health approaches. Skeletal muscle metabolism and fiber type are regulated by innervation and soluble factors, such as thyroid hormones. However, the mechanisms between muscle function and hypothyroidism remain unclear.
Methods: Thirty mice were divided into five subgroups: the normal group; hypothyroid mice (HYPO, 8 mg/kg of propylthiouracil administered via intraperitoneal injection for 30 days); hypothyroid mice treated with DA (gavaged at 0.4 mg/kg for two months, five days per week); hypothyroid mice treated with exercise (75% VO2 max, 45 minutes per session, for two months, five days per week); and hypothyroid mice treated with both DA and exercise. The mRNA expression levels were detected via real-time qPCR.
Results: The data indicated that PPARγ, mTOR, and PI3K levels are reduced in hypothyroidism. DA and exercise enhanced PPARγ, mTOR, and PI3K levels in muscle tissue. Notably, DA and exercise significantly increased the expression levels of PPARγ, mTOR, and PI3K.
Conclusion: Exercise and DA, as alternative and complementary medicine, modified the PPARγ/mTOR/PI3K signaling pathways affected by hypothyroidism in mice.
Kamal Mirkarimi , Najmeh Shahini , Abdolhalim Rajabi , Amir Hosein Izadyar ,
Volume 12, Issue 4 (4-2024)
Abstract
Background: Self-care is defined as a strategy to adapt the events and stresses of life, which improves health and includes special activities that alleviate the symptoms of the disease. This study aimed to investigate the impact of a self-care program on the self-esteem of patients with type 2 diabetes mellitus (T2DM) attending rural health centers in Gorgan City in 2023.
Methods: A quasi-experimental, pre-and post-test intervention study was conducted using a multistage sampling technique in patients with T2DM and prediabetes attending health centers in rural health centers of Gorgan City. An educational program was conducted on 68 patients divided into two groups of diabetes and pre-diabetes (34 patients in each group). Data were collected using a personal information checklist, standard self-care questionnaires, and the Coopersmith Self-Esteem Inventory. Follow-up was conducted two months after the intervention. The data were described using mean and standard deviation, and analyzed by Kolmogorov-Smirnov, Chi-square, Independent T-test, and Paired T-test.
Results: The mean age in the T2DM group was 58 ±7.26, and 60.29 ± 9.47 years in the pre-diabetes group. The mean fasting blood sugar levels in the T2DM and pre-diabetes groups after the intervention were 131.24 and 100.94, respectively, which showed a significant statistical difference (P-Value=0.02). The mean self-esteem scores in the T2DM and pre-diabetes groups after the intervention also showed a significant statistical difference (P-Value =0.006).
Conclusion: In the current study, the present intervention led to the improvement of self-esteem and self-care scores in people with T2DM and pre-diabetes.
Zeinab Mohammadi, Marie Saghaeian Jazi , Seyyed Mehdi Jafari , Seyed Mostafa Mir , Massoud Amanlou , Jahanbakhsh Asadi ,
Volume 12, Issue 4 (4-2024)
Abstract
Background: Bone remodeling involves a balance between osteoblast-driven formation and osteoclast-mediated resorption, with disruptions leading to diseases like osteoporosis. Midazolam (MDZ), known for its sedative properties, has shown effects on cellular differentiation and hydroxyapatite formation in dental cells. However, its role in promoting osteogenic differentiation in human bone marrow mesenchymal stem cells (hBMSCs) remains unexplored, motivating this study to investigate its potential in bone regenerative therapies.
Methods: We purchased hBMSCs from Royan Institute and cultured them in complete media with α-MEM, 10% FBS, and 1% pen/strep. Cell viability was determined with MTT assay in several concentrations of MDZ (0.125 to 1 µM) for 72 hours. Osteogenic differentiation was induced over 21 days using the selected doses of MDZ with osteogenic medium. The Alizarin Red S (ARS) staining was performed to determine the calcium deposit for osteoblast cells. Data were analyzed using repeated measure ANOVA, and a p-value <0.05 was considered statistically significant.
Results: The MTT results for several concentrations of MDZ (0.125 to 1 µM) showed no cytotoxic effects on hBMSCs after 72 hours. Furthermore, ARS staining revealed increased calcium deposits in 0.5 µM MDZ compared to untreated and DMSO groups (p =0.0001). These findings suggest that MDZ promotes mineralization at lower concentrations, highlighting its potential in osteogenic applications, while higher concentrations may lack differentiating effects.
Conclusion: Midazolam promotes osteogenic differentiation of hBMSCs, particularly at 0.5 µM concentration, without cytotoxic effects. These findings demonstrate that MDZ may be a potential compound for osteoblastogenesis; however, these findings require further in vivo studies to confirm the idea.
